Zeuge captured the WBA strap with an impressive knockout victory over Giovanni De Carolis in November at the MBS Arena in Potsdam.
Having fought to a stalemate four months earlier, Zeuge claimed the title in style, stopping the Italian champion with just 19 seconds remaining in the final round.
The Berlin boxer then retained his belt with a technical decision against Nigeria's Isaac Ekpo.
Zeuge is now set for a second defence against former British champion Smith, who returns to Germany for a third attempt at world honours following back-to-back defeats to Arthur Abraham in September 2014 and February 2015.
"Paul Smith is a good opponent with a lot of experience,'' said Zeuge. "I've watched both his fights with Arthur Abraham, and I know he will be coming to win.
"However, I believe his style is well suited to mine, and I'm confident I can beat him. I'm expecting a tough fight, but I guarantee Smith will not take my title!
"I've been training hard with my coaches Juergen Braehmer and Michael Timm. We've prepared a good game plan, and I feel fit and strong.
"It gives me a lot of confidence to have so much experience in my corner. Juergen has been in my position many times before, and he knows what I to do and what advice to give.
"I'm excited to be defending my title. I've worked really hard to get to where I am today and I will not give it up easily.
"I'm the last world champion left in Germany, and while I don't allow myself to feel any additional pressure, I know this is an important fight, not just for me, but for my countrymen too.
"Germany and England have always had a big sporting rivalry. I hope we can give both sets of fans an exciting fight with lots of action.
"Smith has tried and failed to win a world title here twice before, and on Saturday, it will be 3-0 to Germany."
Watch Zeuge v Smith on Saturday night. Coverage begins on Sky Sports 1 HD at 10pm.